Πλοήγηση ανά Συγγραφέα "Spandidos, D. A."
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Angiotensin II up-regulates CX3CR1 expression in THP-1 monocytes: impact on vascular inflammation and atherogenesis
Apostolakis, S.; Vlata, Z.; Vogiatzi, K.; Krambovitis, E.; Spandidos, D. A. (2010)The potential regulatory effect of angiotensins on circulating mononuclear cell activation and migration has not yet been thoroughly evaluated. Using flow cytometry we assessed the possible effect of angiotensin I and II ... -
Applications and Biomonitoring Issues of Recombinant Erythropoietins for Doping Control
Tsitsimpikou, C.; Kouretas, D.; Tsarouhas, K.; Fitch, K.; Spandidos, D. A.; Tsatsakis, A. (2011)The biochemical actions and side effects of recombinant erythropoietins (rhEPOs), their analogs and mimetics, their misuse as doping agents, and the principal analytical strategies developed to identify them in athletes' ... -
Biophysical characterization of V3-lipopeptide liposomes influencing HIV-1 infectivity
Rizos, A. K.; Baritaki, S.; Tsikalas, I.; Doetschman, D. C.; Spandidos, D. A.; Krambovitis, E. (2007)The V3-loop of the HIV-1 gp120 alters host cell immune function and modulates infectivity. We investigated biophysical parameters of liposome constructs with embedded lipopeptides from the principle neutralizing domain of ... -
Confronting multidrug-resistant Acinetobacter baumannii: a review
Neonakis, I. K.; Spandidos, D. A.; Petinaki, E. (2011)Multidrug-resistant Acinetobacter baumannii (MDR-AB) infections are difficult to treat owing to the extremely limited armamentarium. The present review reports all available treatment options against MDR-AB, including ... -
CX3CR1 receptor is up-regulated in monocytes of coronary artery diseased patients: Impact of pre-inflammatory stimuli and renin-angiotensin system modulators
Apostolakis, S.; Krambovitis, E.; Vlata, Z.; Kochiadakis, G. E.; Baritaki, S.; Spandidos, D. A. (2007)Fractalkine/CX3CR1 pathway is considered a major modulator of atherosclerosis. In the present study, expression of CX3CR1 on PBMCs/monocytes of healthy individuals and coronary artery diseased patients was initially assessed ... -
Detection of microsatellite instability in sporadic cardiac myxomas
Sourvinos, G.; Parissis, J.; Sotsiou, F.; Arvanitis, D. L.; Spandidos, D. A. (1999)Objective: Microsatellite instability (MIN) is an early event in DNA repair-deficient associated diseases and reflects an elevated mutation rate in the genome of neoplastic cells. Sporadic cardiac myxomas are the most ... -
Electrostatic modeling of peptides derived from the V3-loop of HIV-1 gp120: Implications of the interaction with chemokine receptor CCR5
Morikis, D.; Rizos, A. K.; Spandidos, D. A.; Krambovitis, E. (2007)Infection of CD4(+) T cells by macrophage-tropic HIV-1 strains involves interaction of viral gp 120 with the host cell chemokine receptor CCR5. The principle neutralizing determinant (PND) of the V3-loop of the HIV-1 gp120 ... -
Evaluation of GenoType Mycobacteria Direct Assay in Comparison with Gen-Probe Mycobacterium tuberculosis Amplified Direct Test and GenoType MTBDRplus for Direct Detection of Mycobacterium tuberculosis Complex in Clinical Samples
Neonakis, I. K.; Gitti, Z.; Baritaki, S.; Petinaki, E.; Baritaki, M.; Spandidos, D. A. (2009)Three molecular assays were evaluated for the direct detection of Mycobacterium tuberculosis complex bacteria in 125 respiratory and 22 nonrespiratory samples. The overall sensitivities obtained were as follows: GenoType ... -
Expression of heregulin in human coronary atherosclerotic lesions
Panutsopulos, D.; Arvanitis, D. L.; Tsatsanis, C.; Papalambros, E.; Sigala, F.; Spandidos, D. A. (2005)Background: Endothelial cells, monocytes/macrophages, and vascular smooth muscle cells contribute to the establishment and progression of atherosclerotic lesions by expressing growth and inflammatory factors. The aim of ... -
Female genital tuberculosis: A review
Neonakis, I. K.; Spandidos, D. A.; Petinaki, E. (2011)Female genital tuberculosis is an uncommon type of tuberculosis that can lead to infertility. The present review describes the disease, reports available epidemiological data, and focuses on examinations and procedures ... -
Geographic variations of human papilloma virus infection and their possible impact on the effectiveness of the vaccination programme
Mammas, I. N.; Vageli, D.; Spandidos, D. A. (2008)Greece is one of the first countries of the European Union to introduce a human. papilloma virus (HPV) vaccine in its national vaccination programme. Geographical variations in the prevalence of the different HPV types ... -
Grape pomace extract exerts antioxidant effects through an increase in GCS levels and GST activity in muscle and endothelial cells
Goutzourelas, N.; Stagos, D.; Housmekeridou, A.; Karapouliou, C.; Kerasioti, E.; Aligiannis, N.; Skaltsounis, A. L.; Spandidos, D. A.; Tsatsakis, A. M.; Kouretas, D. (2015)In a previous study, we demonstrated that a grape pomace extract (GPE) exerted antioxidant activity in endothelial (EA. hy926) and muscle (C2C12) cells through an increase in glutathione (GSH) levels. In the present study, ... -
High-risk human papillomavirus (HPV) in parotid lesions
Vageli, D.; Sourvinos, G.; Ioannou, M.; Koukoulis, G. K.; Spandidos, D. A. (2007)Although several studies have reported that oropharyngeal infection with HPV may predispose to tumorigenesis, little is known about the etiological factors of salivary gland tumors and the presence of HPV. We studied 9 ... -
The HIV-1 gp120/V3 modifies the response of uninfected CD4 T cells to antigen presentation: mapping of the specific transcriptional signature
Morou, A. K.; Porichis, F.; Krambovitis, E.; Sourvinos, G.; Spandidos, D. A.; Zafiropoulos, A. (2011)Background: The asymptomatic phase of HIV-1 infection is characterized by a progressive depletion of uninfected peripheral effector/memory CD4+ T cells that subsequently leads to immune dysfunction and AIDS symptoms. We ... -
HIV-1 gp120/V3-derived epitopes promote activation-induced cell death to superantigen-stimulated CD4(+)/CD45RO(+) T cells
Porichis, F.; Vlata, Z.; Hatzidakis, G.; Spandidos, D. A.; Krambovitis, E. (2007)The third hypervirable (V3) domain of the HIV-1 envelope glycoprotein gp120 has been implicated in HIV pathogenesis via co-receptor usage of chemokine receptors CCR5 and CXCR4. As the protagonist cell populations in the ... -
HIV-1 infection: Is it time to reconsider our concepts?
Krambovitis, E.; Spandidos, D. A. (2006)The long asymptomatic phase of HIV infection is critical in the progression to AIDS. It probably reflects an ancestral relationship with lentiviruses stemming from the primate-simian immunodeficiency virus evolutionary ... -
hMSH2 and hMLH1 gene expression patterns differ between lung adenocarcinoma and squamous cell carcinoma: correlation with patient survival and response to adjuvant chemotherapy treatment
Vageli, D. P.; Zaravinos, A.; Daniil, Z.; Dahabreh, J.; Doukas, S. G.; Spandidos, D. A.; Gourgoulianis, K. I.; Koukoulis, G. K. (2012)Background: We recently showed that the mRNA levels of mismatch repair (MMR) proteins in non-small cell lung carcinoma (NSCLC) tissue specimens and the phenotypic translation of molecular MMR data refines the biology of ... -
IL-1 cytokines in cardiovascular disease: Diagnostic, prognostic and therapeutic implications
Apostolakis, S.; Vogiatzi, K.; Krambovitis, E.; Spandidos, D. A. (2008)Interleukins (ILs) are key mediators in the chronic vascular inflammatory response underlying several aspects of cardiovascular disease. Due to their powerful pro-inflammatory potential, and the fact that they are highly ... -
Is minocycline a solution for multidrugresistant Acinetobacter baumannii?
Neonakis, I. K.; Spandidos, D. A.; Petinaki, E. (2014)Minocycline is an old, safe, second-line antimicrobial agent that has drawn attention over the last fewyears as a possible therapeutic option against multidrug-resistant Acinetobacter baumannii (MDRAB) clinical isolates. ... -
K-ras mutation, HPV infection and smoking or alcohol abuse positively correlate with esophageal squamous carcinoma
Lyronis, I. D.; Baritaki, S.; Bizakis, I.; Krambovitis, E.; Spandidos, D. A. (2008)The Ras/Raf/MEK/ERK (MAPK) signal transduction cascade is an important mediator of a number of cellular fates including growth, survival and apoptosis. The aim of this study was to determine the incidence of B-raf, Kirsten-ras ...